Downs syndrome and Alzheimers are the same diseases according to recent resaerch. Diabetes and cardiovascular disease also share a common disease mechanism. Dr. Potter from Floridas Alzheimers disease research center confirmed this revelation. Downs syndrome and Alzheimers are similar.
Beta-amyloid protein is responsible for damaging the microtubule transport system that transports chromosomes, proteins and other cargo around inside cells. These studies suggest that by protecting the microtubule network from amyloid damage would prevent or reverse Alzheimers and associated conditions.
The study shows that those with Alzheimers have cells with three copies of chromosome 21 instead of the usual two. People who have Downs syndrome share this same defect. Therefore, it is suggested that Alzheimers is a late onset of a form of Down syndrome.
By the time people with down syndrome turn 40, their brain function is similar to that of Alzheimers disease. This includes a nerve-killing buildup of sticky amyloid protein clumps.
according to Dr. Potter, the beta-amyloid creates potholes in the protein highways that move cargo, including chromosomes around inside cells.
When this microtubule network is disrupted, chromosomes can be incorrectly transported as the cells split and new cells with an incorrect number of chromosomes and genes develop.
Dr. Potter suggests:
“Alzheimers disease probably is caused in part from the continuous development of new trisomy 21 nerve cells, which amplify the disease process by producing extra amyloid.”
Research colleague Jose Abisambra suggests another consequence of damaged micro-tubule network – vascular diseases and diabetes. Research teams investigate the role that low-density lipoproteins or bad cholesterol that causes atherosclerosis, cardiovascular diseases and stroke may cause Alzheimers with mixed results. They did, however, focus on the amyloid proteins potential effects on LDL metabolism. This receptor that detects and uses LDL is among the proteins transported by microtubules.
Key proteins such as insulin receptors and brain molecules are locked inside cells when the transport system is damaged by amyloid or others.
Dr. Potter suggests:
“The insulin receptors are needed to get blood sugar inside the cell where it can be used for energy. the nerve cell signaling receptors help promote memory and learning, so if these receptors are unable to function properly, it may lead to diabetes and problems with learning and memory.”
“We are beginning to understand how conditions like cardiovascular disease and diabetes may manifest some of the same underlying processes as Alzheimer’s disease. Rather than being an independent disease that just happens to develop in the same patient.”